Semax

Semax is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax has immunomodulatory, nootropic and neuroprotective activities. Semax can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia.


Cat. No.: EX-A13573	Purity: >99%

	Chemical structure of Semax

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	398	in-stock
500mg	658	in-stock
1g	932	in-stock

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CAS No.	80714-61-0
Purity	>99%
Formula	C37H51N9O10S
Mol Weight	813.92
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL H2O : ? 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder 80°C, 2 years , -20°C, 1 year, Sealed storage, away from moisture; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sciacca MFM, et al. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. ACS Chem Neurosci. 2022 Feb 16;13(4):486-496. [2]. Grivennikov IA, et al. Effects of behaviorally active ACTH (4-10) analogue - Semax on rat basal forebrain cholinergic neurons. Restor Neurol Neurosci. 2008;26(1):35-43. [3]. Shadrina MI, et al. Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog. Neurosci Lett. 2001 Aug 3;308(2):115-8. [4]. Medvedeva EV, et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014 Mar 24;15:228. [5]. Eremin KO, et al. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005 Dec;30(12):1493-500.
CoA	CoA of Semax

Smiles:	C([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@H](CCSC)N)=O)CCC(O)=O)=O)=O)(=O)N3[C@H](C(NCC(=O)N4[C@H](C(O)=O)CCC4)=O)CCC3


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