Selatinib

Selatinib is a reversible and orally active dual EGFR and ErbB2 inhibitor with IC50s of 13 nM and 22.5 nM, respectively. Selatinib has anticancer effects .


Cat. No.: EX-A8607	Purity: >98%

	Chemical structure of Selatinib

For research only, Do not use for Human!

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CAS No.	1275595-86-2
Purity	>98%
Formula	C29H26ClFN4O3S
Mol Weight	565.058
Color	Yellow to orange
State	solid powder
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	4°C, sealed storage, away from moisture and light
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Wang MN, et al. First-in-human, phase I single-ascending-dose study of the safety, pharmacokinetics, and relative bioavailability of selatinib, a dual EGFR-ErbB2 inhibitor in healthy subjects. Invest New Drugs. 2020;38(6):1826-1835. [2].Zhang L, et al. Discovery of a potent dual EGFR/HER-2 inhibitor L-2 (selatinib) for the treatment of cancer. Eur J Med Chem. 2013;69:833-841.
CoA	CoA of Selatinib

Smiles:	O=S(C)CCNCC1=CC=C(O1)C2=CC3=C(N=CN=C3C=C2)NC4=CC=C(C(Cl)=C4)OCC5=CC=CC(F)=C5


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