background


Product Information:

SEL120-34A monohydrochloride

SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respectively, with a Kd of 3 nM for CDK8. SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC50=1070 nM), but shows no obvious activity against CDK1, 2, 4, 6, 5, 7. SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726[1]. Has anti-tumor activity.

Cat. No.: EX-A2929-2    Purity: >98%
Chemical
Chemical structure of SEL120-34A monohydrochloride


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mgget quoteInquire
1gget quote
5gget quote


SynonymsSEL120-34A monohydrochloride
CAS No.2443816-41-7
Purity>98%
FormulaC15H19Br2ClN4
Mol Weight450.599
ColorWhite to off-white
StateSolid
SolubilityH2O : 50 mg/mL DMSO : 16.67 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4°C, sealed storage, away from moisture; In solvent -20°C, 1 year.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8(20):33779-33795.

CoACoA of SEL120-34A monohydrochloride
Smiles:CC1=C2C3=C(C(Br)=C1Br)CCCN3C(N4CCNCC4)=N2.Cl

KEYWORDS: buy SEL120-34A monohydrochloride | SEL120-34A monohydrochloride supplier | purchase | cost | manufacturer | order | distributor | buy 2443816-41-7 | 2443816-41-7 supplier