PNU-159682

PNU-159682, a highly potent metabolite of the anthracycline nemorubicin (DNA topoisomerase II inhibitor) with outstanding cytotoxicity, is a potent ADCs cytotoxin.


Cat. No.: EX-A3364	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	650	In-stock
50mg	990	In-stock
100mg	1350	In-stock
200mg	2200	In-stock
500mg	3500	In-stock
1g	5500	In-stock

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Synonyms	PNU159682
CAS No.	202350-68-3
Purity	>98%
Formula	C32H35NO13
Mol Weight	641.6192
Appearance	Solid powder
Solubility	DMSO >100mg/mL; Insoluble in water
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Quintieri L, et al. Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes. Clin Cancer Res. 2005 Feb 15;11(4):1608-17. [2]. Cazzamalli S, et al. Acetazolamide Serves as Selective Delivery Vehicle for Dipeptide-Linked Drugs to Renal Cell Carcinoma. Mol Cancer Ther. 2016 Dec;15(12):2926-2935.
CoA	CoA of PNU-159682

Smiles:	COC1=C(C(C(C(O)=C([C@@H](O[C@H]2C[C@H]3[C@H](O[C@H]4N3CCO[C@@H]4OC)[C@H](C)O2)C[C@@](C(CO)=O)(O)C5)C5=C6O)=C6C7=O)=O)C7=CC=C1


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