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Product Information:

PX-478

PX-478 is an orally active HIF-1α inhibitor with potent antitumor activities. PX-478 can cross the blood-brain barrier.

Cat. No.: EX-A4655    Purity: >98%
PX-478
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg700In-stock
1g1285In-stock
5gGet quoteIn-stock
10gGet quoteIn-stock


SynonymsPX-478 2HCl
CAS No.685898-44-6
Purity>98%
FormulaC13H20Cl4N2O3
Mol Weight394.121
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Palayoor ST, et al. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer. 2008 Nov 15;123(10):2430-2437.

[2]. Agarwal S, et al. Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E338-47.
CoACoA of PX-478
Smiles:[O-][N+](CCCl)(CCCl)C(C=C1)=CC=C1C[C@H](N)C(O)=O.Cl.Cl

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