CH6953755

CH6953755 is a potent, orally active and selective YES1 kinase (a member of the SRC family) inhibitor with an IC50 of 1.8 nM. CH6953755 inhibits YES1 kinase, leading to antitumor activity against YES1 Gene -amplified cancers in vitro and in vivo.


Cat. No.: EX-A4643	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	750	In-stock
50mg	1050	In-stock
100mg	1550	In-stock
500mg	2500	In-stock
1g	4000	In-stock

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CAS No.	2055918-71-1
Purity	>98%
Formula	C26H22F2N6O4S
Mol Weight	552.552
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hamanaka N, et al. YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification. Cancer Res. 2019 Nov 15;79(22):5734-5745.
CoA	CoA of CH6953755

Smiles:	CS(=O)(NC1=CC2=C(C=C1C)C=C(C(C3=C(N)N(C4=C(C)C=C(OC5=C(F)C=CC=C5F)N=C4)N=C3)=O)N2)=O


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