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Product Information:

Navoximod

Navoximod (GDC-0919, NLG-919) is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) pathway with Ki of 7 nM and EC50 of 75 nM.

Cat. No.: EX-A4607    Purity: >98%
Navoximod
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg785In-stock
250mg1285In-stock
500mg1985In-stock
1g2885In-stock
2g4800In-stock
5g9850In-stock


SynonymsNLG919
Synonyms 2GDC-0919
CAS No.1402837-78-8
Purity>98%
FormulaC18H21FN2O2
Mol Weight316.3699
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Mario R. Mautino, et al. Abstract 491: NLG919, a novel indoleamine-2,3-dioxygenase (IDO)-pathway inhibitor drug candidate for cancer therapy. AACR 104th Annual Meeting 2013; Apr 6-10, 2013.

[2]. Kesarwani, Pravin et al. “Tryptophan Metabolism Contributes to Radiation-Induced Immune Checkpoint Reactivation in Glioblastoma.” Clinical cancer research : an official journal of the American Association for Cancer Research vol. 24,15 (2018): 3632-3643.

[3]. Chen Y, et al. An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy. Nat Commun. 2016 Nov 7;7:13443.

[4]. Li M, et al. The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma. J Immunother Cancer. 2014 Jul 7;2:21.

[5]. Meng, Xiangjing et al. “Combinatorial antitumor effects of indoleamine 2,3-dioxygenase inhibitor NLG919 and paclitaxel in a murine B16-F10 melanoma model.” International journal of immunopathology and pharmacology vol. 30,3 (2017): 215-226.

CoACoA of Navoximod
Smiles:O[C@H](CC1)CC[C@]1([H])[C@H](O)C[C@@H]2N3C(C4=C2C(F)=CC=C4)=CN=C3

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