F-1

F-1 is a potent dual inhibitor of ALK and ROS1 that suppresses phospho-ALK and its relative downstream signaling pathways with IC50 of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively.


Cat. No.: EX-A4556	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	850	In-stock
250mg	1250	In-stock
1g	2850	In-stock

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CAS No.	2244775-31-1
Purity	>98%
Formula	C22H27ClN8O3S
Mol Weight	519.02
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Guo, Ming et al. “Dual potent ALK and ROS1 inhibitors combating drug-resistant mutants: Synthesis and biological evaluation of aminopyridine-containing diarylaminopyrimidine derivatives.” European journal of medicinal chemistry vol. 158 (2018): 322-333.
CoA	CoA of F-1

Smiles:	O=S(NC1=C(NC2=NC(NC3=C(OC)N=C(N4CCN(C)CC4)C=C3)=NC=C2Cl)C=CC=C1)(C)=O


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