SPDB-DM4

SPDB-DM4 is a drug-linker conjugate for ADC by using the maytansinebased payload (DM4, a tubulin inhibitor) via a SPDB linker, exhibiting potent anti-tumor activity.


Cat. No.: EX-A4520	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	1100	In-stock
10mg	1800	In-stock
100mg	Get quote	In-stock
500mg	Get quote	In-stock

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CAS No.	1626359-62-3
Purity	>98%
Formula	C46H63ClN4O14S2
Mol Weight	995.594
Appearance	white solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under 0-8 degree Celcius as non-hazardous chemical. Shipping with dry ice upon request. (Cold Chain Logistics by FedEx)

Reference:	[1]. Erickson, Hans K et al. Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer research vol. 66,8 (2006): 4426-33. [2]. Kellogg, Brenda A et al. Disulfide-linked antibody-maytansinoid conjugates: optimization of in vivo activity by varying the steric hindrance at carbon atoms adjacent to the disulfide linkage. Bioconjugate chemistry vol. 22,4 (2011): 717-27.
CoA	CoA of SPDB-DM4

Smiles:	C[C@]1([C@H](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCC(C)(C)SSCCCC(ON(C4=O)C(CC4)=O)=O)=O)=O)[C@H]([C@@H]([C@](OC5=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N5)O)C)O1


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