TC-G 1005

TC-G 1005 is a potent and selective TGR5 (GPBAR1) agonist with (EC50 :0.72 nM; hTGR5). TC-G 1005 is selective for TGR5 over FXR (farnesoid X receptor).


Cat. No.: EX-A4487	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	300	In-stock
25mg	500	In-stock
50mg	750	In-stock
100mg	1050	In-stock
200mg	1550	In-stock

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CAS No.	1415407-60-1
Purity	>98%
Formula	C25H25N3O2
Mol Weight	399.4849
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Duan H, Ning M, Chen X, Zou Q, Zhang L, Feng Y, Zhang L, Leng Y, Shen J. Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J Med Chem. 2012 Dec 13;55(23):10475-89. doi: 10.1021/jm301071h. Epub 2012 Nov 29. PubMed PMID: 23148522.
CoA	CoA of TC-G 1005

Smiles:	CC1=CC(=C(C=C1)C)OC2=C(C=NC=C2)C(=O)N3CCN(C4=CC=CC=C43)C5CC5


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