CMS-121

CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively.


Cat. No.: EX-A4377	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
100mg	785	In-stock
250mg	1085	In-stock

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Synonyms	CMS121
CAS No.	1353224-53-9
Purity	>98%
Formula	C20H19NO3
Mol Weight	321.3698
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Chiruta, C., Schubert, D., Dargusch, R., et al. Chemical modification of the multi-target neuroprotective compound fisetin. J. Med. Chem. 55(1), 378-389 (2012). [2]. Prior, M., Chiruta, C., Currais, A., et al. Back to the future with phenotypic screening. ACS Chem Neurosci. 5(7), 503-513 (2014). [3]. Currais, A., Maher, P., Schubert, D., et al. Prevention and treatment of aging and neurodegenerative diseases. (2017).
CoA	CoA of CMS-121

Smiles:	OC1=CC=C(C2=NC3=CC=CC=C3C(OC4CCCC4)=C2)C=C1O


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