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Product Information:

ASTX-029

ASTX-029 is an orally bioavailable dual ERK1/2 inhibitor. ASTX-029 has anti-cancer activity.

Cat. No.: EX-A4375    Purity: >98%
ASTX-029
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg550In-stock
100mg700In-stock
200mg1100In-stock
500mg1800In-stock
1g3100In-stock
5gget quoteIn-stock


SynonymsASTX029
CAS No.2095719-92-7
Purity>98%
FormulaC29H31ClFN5O5
Mol Weight584.038
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Heightman TD, et al. Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J Med Chem. 2021 Aug 26;64(16):12286-12303. doi: 10.1021/acs.jmedchem.1c00905. Epub 2021 Aug 13. PMID: 34387469.

[2]. Munck JM, et al. ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK. Mol Cancer Ther. 2021 Oct;20(10):1757-1768. doi: 10.1158/1535-7163.MCT-20-0909. Epub 2021 Jul 30. PMID: 34330842.
CoACoA of ASTX-029
Smiles:ClC(C(C1=CC2=C(CN([C@H](C)C(N[C@H](CO)C3=CC(F)=CC(OC)=C3)=O)C2=O)C=C1)=N4)=CN=C4NC5CCOCC5

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