IACS-13909

IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers.


Cat. No.: EX-A4355	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	550	In-stock
100mg	750	In-stock
250mg	1150	In-stock
1g	2200	In-stock
5g	6850	In-stock
10g	10960	In-stock

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CAS No.	2160546-07-4
Purity	>98%
Formula	C17H18Cl2N6
Mol Weight	377.271
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yuting Sun, et al. Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res. 2020 Nov 1;80(21):4840-4853.
CoA	CoA of IACS-13909


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