Tipranavir

Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM. Tipranavir inhibits SARS-CoV-2 3CLpro activity.


Cat. No.: EX-A4113	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	750	In-stock
250mg	1250	In-stock
500mg	2200	In-stock
1g	3520	In-stock
5g	14800	In-stock
10g	13500	In-stock

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Synonyms	PNU-140690
CAS No.	174484-41-4
Purity	>98%
Formula	C31H33F3N2O5S
Mol Weight	602.664
Appearance	solid powder
Solubility	Soluble in DMSO, Ethanol
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Aoki M, et al. Loss of the protease dimerization inhibition activity of tipranavir (TPV) and its association with the acquisition of resistance to TPV by HIV-1. J Virol. 2012 Dec;86(24):13384-96. [2]. Li F, et al. Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice. Drug Metab Dispos. 2010 May;38(5):871-8. [3]. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
CoA	CoA of Tipranavir

Smiles:	O=C1C([C@H](CC)C2=CC=CC(NS(C3=CC=C(C(F)(F)F)C=N3)(=O)=O)=C2)=C(O)C[C@](CCC4=CC=CC=C4)(CCC)O1


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