Product Information:
Cat. No.: EX-A4015 | Purity: >98% |
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Synonyms | CM272 |
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CAS No. | 1846570-31-7 |
Purity | >98% |
Formula | C28H38N4O3 |
Mol Weight | 478.6263 |
Appearance | solid powder |
Solubility | Soluble in DMSO |
Shelf Life | >2 years if stored properly |
Storage | Powder -20℃ 2 years; In solvent -20℃ 1 month; |
Shipping | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Reference: | [1]. E San José-Enériz et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.
[2]. E Rabal O, San José-Enériz et al. Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy. J Med Chem. 2018 Aug 9;61(15):6518-6545. [3]. JA Rabal O, Sánchez-Arias et al. Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces. J Med Chem. 2018 Aug 9;61(15):6546-6573. [4]. M Bárcena-Varela et al. Dual Targeting of Histone Methyltransferase G9a and DNA-Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma. Hepatology. 2019 Feb;69(2):587-603. |
CoA | CoA of CM-272 |
Smiles: | CN(CC1)CCC1NC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C42 |
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