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Product Information:

CM-272

CM-272 is a first-in-class potent, selective and reversible inhibitor of histone methyltransferase G9a and DNA-methyltransferase 1 with IC50 values of 8nM and 382 nM, respectively.

Cat. No.: EX-A4015    Purity: >98%
CM-272
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg650In-stock
250mg1000In-stock
500mg1500In-stock
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SynonymsCM272
CAS No.1846570-31-7
Purity>98%
FormulaC28H38N4O3
Mol Weight478.6263
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. E San José-Enériz et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.

[2]. E Rabal O, San José-Enériz et al. Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy. J Med Chem. 2018 Aug 9;61(15):6518-6545.

[3]. JA Rabal O, Sánchez-Arias et al. Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces. J Med Chem. 2018 Aug 9;61(15):6546-6573.

[4]. M Bárcena-Varela et al. Dual Targeting of Histone Methyltransferase G9a and DNA-Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma. Hepatology. 2019 Feb;69(2):587-603.
CoACoA of CM-272
Smiles:CN(CC1)CCC1NC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C42

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