Vonoprazan Fumarate

onoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion.


Cat. No.: EX-A4001	Purity: >99%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
50mg	385	In-stock
200mg	885	In-stock

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Synonyms	TAK438
CAS No.	881681-01-2
Purity	>99%
Formula	C21H20FN3O6S
Mol Weight	461.463
Appearance	solid powder
Solubility	Soluble in DMSO, not in water
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Arikawa, Yasuyoshi et al. “Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). Journal of medicinal chemistry vol. 55,9 (2012): 4446-56. [2]. Hori, Yasunobu et al. “1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. The Journal of pharmacology and experimental therapeutics vol. 335,1 (2010): 231-8.
CoA	CoA of Vonoprazan Fumarate

Smiles:	O=C(O)/C=C/C(O)=O.O=S(N1C=C(CNC)C=C1C2=CC=CC=C2F)(C3=CC=CN=C3)=O.[(E)]


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