(S,R,S)-AHPC-Me

(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader.


Cat. No.: EX-A3906	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25g	985	In-stock
50g	1685	In-stock
100g	2585	In-stock

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Synonyms	E3 ligase Ligand 1A
Synonyms 2	VHL ligand 2
CAS No.	1948273-02-6
Purity	>98%
Formula	C23H32N4O3S
Mol Weight	444.59
Appearance	solid powder
Solubility	Soluble in DMSO and water
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. WO/2017/030814A1 [2]. Raina K, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7124-9.
CoA	CoA of (S,R,S)-AHPC-Me

Smiles:	N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O


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