RU320521

RU320521 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 700 nM.


Cat. No.: EX-A3736	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	625	In-stock
250mg	985	In-stock
500mg	1385	In-stock
1g	1950	In-stock
5g	7400	In-stock

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Synonyms	RU.521
CAS No.	2262452-06-0
Purity	>98%
Formula	C19H12Cl2N4O3
Mol Weight	415.23
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Vincent J, et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750.
CoA	CoA of RU320521

Smiles:	O=C1OC(C2=C(O)N(C3=NC4=CC=C(Cl)C(Cl)=C4N3)N=C2C)C5=C1C=CC=C5


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