TH1020

TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist with an IC50 of 0.85 μM. TH1020 inhbits flagellin-induced TLR5 signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8.


Cat. No.: EX-A3696	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	485	In-stock
250mg	800	In-stock
500mg	1285	In-stock
1g	1885	In-stock
2g	3050	In-stock
5g	5625	In-stock

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CAS No.	1841460-82-9
Purity	>98%
Formula	C23H15N7S2
Mol Weight	453.542
Appearance	solid powder
Solubility	DMSO : 2 mg/mL (4.41 mM; ultrasonic and warming and adjust pH to 2 with 1M HCl and heat to 80°C)
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Lei Yan, et al. Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors. ChemMedChem. 2016 Apr 19;11(8):822-6. [2]. Yu Luo, et al. Toll-like Receptor 5-mediated IL-17C Expression in Intestinal Epithelial Cells Enhances Epithelial Host Defense Against F4 + ETEC Infection. Vet Res. 2019 Jun 20;50(1):48.
CoA	CoA of TH1020

Smiles:	C12=NC=NC(SC3=NN=C(N3CC4=CC=CC=C4)C5=CC=NC=C5)=C1SC6=NC=CC=C62


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