Elexacaftor

Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.


Cat. No.: EX-A3637	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	750	Inquire
500mg	1250	In-stock
1g	1950	In-stock
2g	3500	In-stock
3g	4900	In-stock
5g	7600	In-stock

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Synonyms	VX-445
CAS No.	2216712-66-0
Purity	>98%
Formula	C26H34F3N7O4S
Mol Weight	597.653
Appearance	white to off-white solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Keating D, et al. VX-445-Tezacaftor-VX-770 in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. N Engl J Med. 2018 Oct 25;379(17):1612-1620. [2]. Alexander Russell Abela, et al. MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR , PHARMACEUTICAL COMPOSITIONS , METHODS OF TREATMENT , AND PROCESS FOR MAKING THE MODULATOR. US 20180162839 A1.
CoA	CoA of Elexacaftor
SDS	SDS of Elexacaftor

Smiles:	CC1(C)C[C@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2


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