Molnupiravir

Molnupiravir, also known as EIDD-2801 and MK-4482, is an orally bioavailable form of a highly potent ribonucleoside analog that inhibits the replication of multiple RNA viruses including SARS-CoV-2, the causative agent of COVID-19. EIDD-2801 has been shown to improve pulmonary function, decrease body weight loss and reduce the amount of virus in the lung. In addition to activity against coronaviruses, EIDD-2801, in laboratory studies, has demonstrated activity against seasonal and bird influenza, respiratory syncytial virus, chikungunya virus, Ebola virus, Venezuelan equine encephalitis virus, and Eastern equine encephalitis virus. EIDD-2801 is a prodrug of EIDD-1931.


Cat. No.: EX-A3558	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	350	In-stock
250mg	450	In-stock
500mg	600	In-stock
1g	880	In-stock
5g	2200	In-stock
10g	3350	In-stock

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Synonyms	MK-4482
Synonyms 2	EIDD-2801
Purity	>98%
Formula	C13H19N3O7
Mol Weight	329.3059
Appearance	white solid powder
Solubility	Soluble in DMSO and water
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 1 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Timothy P. Sheahan, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Science Translational Medicine 06 Apr 2020:eabb5883 DOI: 10.1126/scitranslmed.abb5883 [2]. Hampton T. New Flu Antiviral Candidate May Thwart Drug Resistance. JAMA. 2020 Jan 7;323(1):17. doi: 10.1001/jama.2019.20225. PMID: 31910262. [3]. Toots M, Yoon JJ, Hart M, Natchus MG, Painter GR, Plemper RK. Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model. Transl Res. 2020 Apr;218:16-28. doi: 10.1016/j.trsl.2019.12.002. Epub 2019 Dec 25. PMID: 31945316. [4]. Toots M, Yoon JJ, Cox RM, Hart M, Sticher ZM, Makhsous N, Plesker R, Barrena AH, Reddy PG, Mitchell DG, Shean RC, Bluemling GR, Kolykhalov AA, Greninger AL, Natchus MG, Painter GR, Plemper RK. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci Transl Med. 2019 Oct 23;11(515):eaax5866. doi: 10.1126/scitranslmed.aax5866. PMID: 31645453; PMCID: PMC6848974.
CoA	CoA of Molnupiravir
HNMR	HNMR of Molnupiravir

Smiles:	O[C@H]1[C@@H](O)[C@H](N2C(N=C(NO)C=C2)=O)O[C@@H]1COC(C(C)C)=O


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