E1210

Manogepix (E1210) is a first-in-class, broad-spectrum and orally active antifungal. Manogepix has a mechanism of action-inhibition of fungal glycosylphosphatidylinositol (GPI) biosynthesis.


Cat. No.: EX-A3405	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	885	In-stock
200mg	1285	In-stock
500mg	1985	In-stock
1g	2800	In-stock
2g	4600	In-stock
5g	7500	Inquire

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Synonyms	Manogepix
Synonyms 2	APX001A
CAS No.	936339-60-5
Purity	>98%
Formula	C21H18N4O2
Mol Weight	358.3932
Appearance	Solid powder
Solubility	Soluble in DMSO, >100mg/mL;
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Watanabe NA, et al. E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis. Antimicrob Agents Chemother. 2012 Feb;56(2):960-71. [2]. Hata K, et al. Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis. Antimicrob Agents Chemother. 2011 Oct;55(10):4543-51.
CoA	CoA of E1210

Smiles:	NC1=NC=CC=C1C2=CC(CC3=CC=C(COC4=NC=CC=C4)C=C3)=NO2


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