Dapagliflozin (2S)-1,2-propanediol hydrate

Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine. Dapagliflozin ((2S)-1,2-propanediol, hydrate) induces HIF1 expression and attenuates renal IR injury.


Cat. No.: EX-A2824	Purity: >99%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	350	In-stock
200mg	385	In-stock
500mg	400	In-stock
1g	485	In-stock
5g	985	In-stock
10g	1550	In-stock

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Synonyms	BMS-512148 propanediol monohydrate
Synonyms 2	BMS-512148 (2S)-1,2-propanediol hydrate
CAS No.	960404-48-2
Purity	>99%
Formula	C24H35ClO9
Mol Weight	502.982
Appearance	solid powder
Solubility	Soluble in DMSO, Ethanol
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Meng, Wei et al. Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. Journal of medicinal chemistry vol. 51,5 (2008): 1145-9. [2]. Han, Songping et al. Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes vol. 57,6 (2008): 1723-9.
CoA	CoA of Dapagliflozin (2S)-1,2-propanediol hydrate

Smiles:	O.C[C@H](O)CO.CCOC1=CC=C(CC2=C(Cl)C=CC(=C2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=C1


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