PF-477736

PF-00477736, (PF-477736), is a potent CHK1 inhibitor with potential chemopotentiation activity. PF-477736 inhibits chk1, an ATP-dependent serine-threonine kinase that is a key component in the DNA replication-monitoring S/G2 checkpoint system. By overriding the last checkpoint defense against DNA damaging agent-induced lethal damage, chk1 inhibitor PF-477736 may potentiate the antitumor efficacy of various chemotherapeutic agents against tumor cells with intrinsic checkpoint defects.


Cat. No.: EX-A2131	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	550	In-stock
250mg	900	In-stock
1g	1685	In-stock
5g	5000	In-stock
custom siz	Get quote

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Synonyms	1071848-28-6
CAS No.	952021-60-2
Purity	>98%
Formula	C22H25N7O2
Mol Weight	419.4796
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Restelli V, Lupi M, Vagni M, Chilà R, Bertoni F, Damia G, Carrassa L. Combining Ibrutinib with Chk1 Inhibitors Synergistically Targets Mantle Cell Lymphoma Cell Lines. Target Oncol. 2018 Apr;13(2):235-245. doi: 10.1007/s11523-018-0553-6. PubMed PMID: 29441438. [2]. Restelli V, Chilà R, Lupi M, Rinaldi A, Kwee I, Bertoni F, Damia G, Carrassa L. Characterization of a mantle cell lymphoma cell line resistant to the Chk1 inhibitor PF-00477736. Oncotarget. 2015 Nov 10;6(35):37229-40. doi: 10.18632/oncotarget.5954. PubMed PMID: 26439697; PubMed Central PMCID: PMC4741926. [3]. Kim MK, James J, Annunziata CM. Topotecan synergizes with CHEK1 (CHK1) inhibitor to induce apoptosis in ovarian cancer cells. BMC Cancer. 2015 Mar 28;15:196. doi: 10.1186/s12885-015-1231-z. PubMed PMID: 25884494; PubMed Central PMCID: PMC4379550.
CoA	CoA of PF-477736

Smiles:	CN1C=C(C=N1)C1=C2C=NNC(=O)C3=CC(NC(=O)[C@H](N)C4CCCCC4)=CC(N1)=C23


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