RO5126766

RO5126766(CH5126766, VS-6766,CKI-27) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM,19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively.


Cat. No.: EX-A2151	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	600	In-stock
200mg	900	In-stock
500mg	1300	In-stock
1g	1950	In-stock
5g	5500	In-stock
10g	7950	In-stock

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Synonyms	CH5126766
Synonyms 2	VS-6766
CAS No.	946128-88-7
Purity	>98%
Formula	C21H18FN5O5S
Mol Weight	471.462
Appearance	solid powder
Solubility	Soluble in DMSO, not in water
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ishii, Nobuya et al. Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity. Cancer research vol. 73,13 (2013): 4050-4060. [2]. Tegnebratt, Tetyana et al. [18 F]FDG-PET imaging is an early non-invasive pharmacodynamic biomarker for a first-in-class dual MEK/Raf inhibitor, RO5126766 (CH5126766), in preclinical xenograft models. EJNMMI research vol. 3,1 67. 16 Sep. 2013. [3]. Wada, Makoto et al. The dual RAF/MEK inhibitor CH5126766/RO5126766 may be a potential therapy for RAS-mutated tumor cells. PloS one vol. 9,11 e113217. 25 Nov. 2014.
CoA	CoA of RO5126766

Smiles:	CNS(=O)(=O)NC1=NC=CC(CC2=C(C)C3=CC=C(OC4=NC=CC=N4)C=C3OC2=O)=C1F


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