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Product Information:

INCB14943

INCB024360 analogue (INCB14943, IDO5L) is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nM.

Cat. No.: EX-A2076    Purity: >98%
INCB14943
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg485In-stock
500mg685In-stock
1g935In-stock
5g2885In-stock


SynonymsIDO5L
Synonyms 2INCB024360 analogue
CAS No.914471-09-3
Purity>98%
FormulaC9H7ClFN5O2
Mol Weight271.636
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Yue EW, et al. Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J Med Chem. 2009 Dec 10;52(23):7364-7.

[2]. Huang X, et al. Synthesis of [(18) F] 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide (IDO5L): a novel potential PET probe for imaging of IDO1 expression. J Labelled Comp Radiopharm. 2015 Apr;58(4):156-62.

[1]. Steeneck, Christoph et al. “Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation.” ACS medicinal chemistry letters vol. 11,2 179-187. 27 Jan. 2020

CoACoA of INCB14943
Smiles:NC1=NON=C1\C(NC1=CC=C(F)C(Cl)=C1)=N\O

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