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Product Information:

Veliparib dihydrochloride

Veliparib (dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Kis of 5.2 nM and 2.9 nM in cell-free assays, respectively.

Cat. No.: EX-A2823    Purity: >98%
Veliparib
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg335In-stock
500mg500In-stock
1g650In-stock
5g1250In-stock
10g1850In-stock


SynonymsABT-888 dihydrochloride
CAS No.912445-05-7
Purity>98%
FormulaC13H18Cl2N4O
Mol Weight317.214
Appearancesolid powder
SolubilitySoluble in water
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Donawho CK, et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res. 2007 May 1;13(9):2728-37.

[2]. Penning TD, et al. Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. J Med Chem. 2009 Jan 22;52(2):514-23.

[3]. Albert JM, et al. Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin Cancer Res. 2007 May 15;13(10):3033-42.

[4]. Robert J. Kinders, et al. Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts. Clin Cancer Res. Author manuscript; available in PMC 2009 Nov 1.

CoACoA of Veliparib dihydrochloride
Smiles:Cl.Cl.C[C@@]1(CCCN1)C1=NC2=CC=CC(C(N)=O)=C2N1

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