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Product Information:

GDC-0879

GDC-0879 is a potent and selective B-Raf inhibitor with an IC50 of 0.13 nM.

Cat. No.: EX-A2357    Purity: >98%
GDC-0879
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg900In-stock
500mg1650In-stock
1g2500In-stock


CAS No.905281-76-7
Purity>98%
FormulaC19H18N4O2
Mol Weight334.3718
AppearanceSolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Hansen JD, et al. Potent and selective pyrazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4692-5.

[2]. Wong H, et al. Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy. J Pharmacol Exp Ther. 2009 Apr;329(1):360-7.

CoACoA of GDC-0879
Smiles:OCCN1C=C(C(=N1)C1=CC=NC=C1)C1=CC2=C(C=C1)\C(CC2)=N\O

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