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Product Information:

EMD534085

EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM.

Cat. No.: EX-A2369    Purity: >98%
EMD534085
For research only, Do not use for Human!

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CAS No.858668-07-2
Purity>98%
FormulaC25H31F3N4O2
Mol Weight476.5344
Appearancewhite to off-white solid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Schiemann K, et al. The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1491-5.

[2]. Tang Y, et al. Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells. Cancer Lett. 2011 Nov 1;310(1):15-24.

CoACoA of EMD534085
Smiles:[H][C@@]12CC[C@H](CNC(=O)NCCN(C)C)O[C@]1([H])C1=C(N[C@H]2C2=CC=CC=C2)C=CC(=C1)C(F)(F)F

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