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Product Information:

YM-155

Sepantronium bromide (YM-155) is a survivin inhibitor with an IC50 of 0.54 nM.

Cat. No.: EX-A2187    Purity: >98%
YM-155
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg350In-stock
250mg550In-stock
500mg750In-stock
1g1050In-stock
5g2950In-stock
10g4425In-stock


SynonymsSepantronium bromide
CAS No.781661-94-7
Purity>98%
FormulaC20H19BrN4O3
Mol Weight443.294
Appearancesolid powder
SolubilityDMSO : 50 mg/mL (112.79 mM; Need ultrasonic); H2O : 50 mg/mL (112.79 mM; Need ultrasonic)
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Nakahara T, et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 2007 Sep 1;67(17):8014-21.

[2]. Iisa T, et al. Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin Cancer Res. 2008 Oct 15;14(20):6496-504.

[3]. Guo K, et al. A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model. Oncotarget. 2015 Aug 28;6(25):21137-47.

CoACoA of YM-155
Smiles:[Br-].COCCN1C(C)=[N+](CC2=NC=CN=C2)C2=C1C(=O)C1=CC=CC=C1C2=O

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