Pirmenol

Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation.


Cat. No.: EX-A2926	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	300	In-stock
500mg	450	In-stock
1g	750	In-stock
5g	2800	In-stock

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Synonyms	(±)-Pirmenol
Synonyms 2	CI-845 free base
CAS No.	68252-19-7
Purity	>98%
Formula	C22H30N2O
Mol Weight	338.4864
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Watanabe Y, et al. Pirmenol inhibits muscarinic acetylcholine receptor-operated K+ current in the guinea pig heart. Eur J Pharmacol. 1997 Oct 29;338(1):71-4. [2]. Schardein JL, et al. Preclinical toxicology studies with a new antiarrhythmic agent: Pirmenol hydrochloride (CI-845). Toxicol Appl Pharmacol. 1980 Nov;56(2):294-301. [3]. T Sawanobori, et al. Electrophysiologic and antiarrhythmic actions of pirmenol on rabbit and guinea pig cardiac preparations. J Cardiovasc Pharmacol. 1990 Dec;16(6):975-83. [4]. T E Mertz, et al. Pirmenol hydrochloride (CI-845): antiarrhythmic profile in coronary artery ligated conscious dogs. J Cardiovasc Pharmacol. 1980 Sep-Oct;2(5):527-41.
CoA	CoA of Pirmenol

Smiles:	C[C@H]1CCC[C@@H](C)N1CCCC(O)(C1=CC=CC=C1)C1=CC=CC=N1


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