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Product Information:

E-64

E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general cysteine proteases with IC50 of 9 nM for papain.

Cat. No.: EX-A2284    Purity: >98%
E-64
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg635In-stock
500mg825In-stock
1g985In-stock
5g3695In-stock
10g5950In-stock


SynonymsProteinase inhibitor E 64
CAS No.66701-25-5
Purity>98%
FormulaC15H27N5O5
Mol Weight357.4054
Appearancewhite powder
SolubilitySoluble in DMSO, 20.0mg/ml in Water clear soluble
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Matsumoto K, et al. Structural basis of inhibition of cysteine proteases by E-64 and its derivatives. Biopolymers. 1999;51(1):99-107.

[2]. Wadhawan M, et al. Inhibition of cathepsin B by E-64 induces oxidative stress and apoptosis in filarial parasite. PLoS One. 2014 Mar 25;9(3):e93161.

[3]. Baldzizhar R, et al. Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes. J Biol Chem. 2013 Jan 18;288(3):1612-9.

[4]. Blass G, et al. Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats. Physiol Rep. 2016 Sep;4(17). pii: e12950.

CoACoA of E-64
Smiles:CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(O)=O)C(=O)NCCCCNC(N)=N

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