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Product Information:

Tubacin

Tubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1.

Cat. No.: EX-A2172    Purity: >98%
Tubacin
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
25mg885In-stock
50mg1285In-stock
100mg1885In-stock
200mg3300In-stock


CAS No.537049-40-4
Purity>98%
FormulaC41H43N3O7S
Mol Weight721.861
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Butler KV, et al. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.

[2]. Hideshima T, et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8567-72. Epub 2005 Jun 3.

[3]. Lu CY, et al. Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. Int J Mol Sci. 2017 May 1;18(5).
CoACoA of Tubacin
Smiles:OCC1=CC=C(C=C1)[C@@H]1C[C@H](CSC2=NC(=C(O2)C2=CC=CC=C2)C2=CC=CC=C2)O[C@@H](O1)C1=CC=C(NC(=O)CCCCCCC(=O)NO)C=C1

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