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Product Information:

TPPB

TPPB (α-Amyloid Precursor Protein Modulator) is a cell-permeable benzolactam-derived protein kinase C (PKC) activator with a Ki of 11.9 nM.

Cat. No.: EX-A2507    Purity: >98%
TPPB
For research only, Do not use for Human!

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SynonymsAmyloid Precursor Protein Modulator
Synonyms 2α-Amyloid Precursor Protein Modulator
CAS No.497259-23-1
Purity>98%
FormulaC27H30F3N3O3
Mol Weight501.5406
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Kozikowski AP, et al. New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha. J Med Chem. 2003 Jan 30;46(3):364-73.

[2]. Yang HQ, et al. Neuroprotective effects of new protein kinase C activator TPPB against Aβ25-35 induced neurotoxicity in PC12 cells. Neurochem Res. 2012 Oct;37(10):2213-21.
CoACoA of TPPB
Smiles:CC(C)[C@@H]1N(C)C2=CC=C(NC(=O)\C=C\C=C\C3=CC=C(C=C3)C(F)(F)F)C=C2C[C@@H](CO)NC1=O

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