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Product Information:

Marizomib

Marizomib (NPI-0052) is second-generation, irreversible, brain-penetrant, pan-proteasome inhibitor.

Cat. No.: EX-A3259    Purity: >98%
Marizomib
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
5mg1050In-stock
10mg1550In-stock
50mgGet quoteinquire
100mgGet quoteinquire
200mgGet quoteinquire
500mgGet quoteinquire


SynonymsNPI-0052
Synonyms 2Salinosporamide A
CAS No.437742-34-2
Purity>98%
FormulaC15H20ClNO4
Mol Weight313.777
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Chauhan, Dharminder et al. Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma. Blood vol. 115,4 (2010): 834-45.

[1]. Singh, Ajita V et al. Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI-0052 (marizomib) in a human plasmacytoma xenograft murine model. British journal of haematology vol. 149,4 (2010): 550-9.

CoACoA of Marizomib
Smiles:O=C([C@H](CCCl)[C@]1(C)O2)N[C@@]1([C@H]([C@@H]3C=CCCC3)O)C2=O

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