IMR-1

IMR-1 is a Mastermind Recruitment inhibitor. IMR-1 disrupted the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex on chromatin, thereby attenuating Notch target gene transcription. IMR-1 inhibited the growth of Notch-dependent cell lines and significantly abrogated the growth of patient-derived tumor xenografts.


Cat. No.: EX-A2021	Purity: 0.987

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	650	In-stock
1g	895	In-stock
5g	2565	In-stock
10g	3985	In-stock

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CAS No.	310456-65-6
Purity	0.987
Formula	C15H15NO5S2
Mol Weight	353.413
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Astudillo L, Da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver K, Oashi T, Lopes PE, Orton D, Neitzel LR, Lee E, Landgraf R, Robbins DJ, MacKerell AD Jr, Capobianco AJ. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603. doi: 10.1158/0008-5472.CAN-16-0061. PubMed PMID: 27197169; PubMed Central PMCID: PMC4911243. [2]. Svinogeeva TP, Kharlampovich SI. [Effeco of sarcolysine on the growth and morphological characteristics of IMR-1 sarcoma]. Vopr Onkol. 1974;20(4):98-9. Russian. PubMed PMID: 4439824. [3]. Kharlampovich SI. [Combined drug and radiation therapy of IMR-1 sarcoma with regard to its mitotic activity]. Vopr Onkol. 1970;16(1):75-82. Russian. PubMed PMID: 5434579. [4]. Kharlampovich SI, Podsosov SP. [Transplanted sarcoma (IMR-1) in "August" strain rats]. Vopr Onkol. 1966 Apr;12(4):83-6. Russian. PubMed PMID: 6001005.
CoA	CoA of IMR-1

Smiles:	CCOC(=O)COC1=CC=C(\C=C2\SC(=S)NC2=O)C=C1OC


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