Zotarolimus

Zotarolimus (ABT-578) is a semi-synthetic rapamycin analog with immunosuppressant and anti-proliferative activity. It binds to the FKBP12 binding protein, which subsequently binds to the mammalian target of rapamycin (mTOR) causing cell cycle arrest in the G1 phase. Zotarolimus was designed to be used for delivery from drug-eluting coronary stents to prevent restenosis.

Zotarolimus is a second generation Drug Eluting Stent (DES).


Cat. No.: EX-A2216	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	500	In-stock
250mg	900	In-stock
1g	1850	In-stock
5g	6500	Inquire
custom siz	Get quote

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Synonyms	ABT-578
CAS No.	221877-54-9
Purity	>98%
Formula	C52H79N5O12
Mol Weight	966.21
Appearance	white to off-white powder
Solubility	Soluble in DMSO, not in water
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kufner S, Sorges J, Mehilli J, Cassese S, Repp J, Wiebe J, Lohaus R, Lahmann A, Rheude T, Ibrahim T, Massberg S, Laugwitz KL, Kastrati A, Byrne RA; ISAR-TEST-5 Investigators. Randomized Trial of Polymer-Free Sirolimus- and Probucol-Eluting Stents Versus Durable Polymer Zotarolimus-Eluting Stents: 5-Year Results of the ISAR-TEST-5 Trial. JACC Cardiovasc Interv. 2016 Apr 25;9(8):784-92. doi: 10.1016/j.jcin.2016.01.009. Epub 2016 Mar 23. PubMed PMID: 27017366. [2]. Markovic S, Lützner M, Rottbauer W, Wöhrle J. Zotarolimus compared with everolimus eluting stents-angiographic and clinical results after recanalization of true coronary chronic total occlusions. Catheter Cardiovasc Interv. 2016 Mar 4. doi: 10.1002/ccd.26482. [Epub ahead of print] PubMed PMID: 26945903. [3]. Lin L, Jin C, Wei X, Li H, Shi J, Wu S, Yang X, Qi X. Comparison on the efficacy of everolimus-eluting stent and zotarolimus-eluting stents in coronary heart disease between diabetic and non-diabetic patients. Int J Clin Exp Med. 2015 Nov 15;8(11):20813-20. eCollection 2015. PubMed PMID: 26885005; PubMed Central PMCID: PMC4723850. [4 ]. Marco V, et al. Zotarolimus-eluting versus bare-metal stents in uncertain drug-eluting stent candidates Valgimigli M, et al. Journal of the American College of Cardiology 65(8), 805-815, (2015)
CoA	CoA of Zotarolimus

Smiles:	[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])(CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H]([C@@H](C1)OC)N1C=NN=N1


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