AZD5991

AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM). The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1.


Cat. No.: EX-A2673	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	1650	In-stock
200mg	2685	In-stock
1g	Get quote	In-stock

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Synonyms	AZD-5991
CAS No.	2143061-81-6
Purity	>98%
Formula	C35H34ClN5O3S2
Mol Weight	672.259
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Tron, Adriana E et al. “Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.” Nature communications vol. 9,1 5341. 17 Dec. 2018 [2]. Garner, Thomas P et al. “Progress in targeting the BCL-2 family of proteins.” Current opinion in chemical biology vol. 39 (2017): 133-142. [3]. Adriana E. Tron, et al. Selective Mcl-1 inhibition by AZD5991 induces on-target cell death and achieves antitumor activity in multiple myeloma and acute myeloid leukemia. AACR Cancer Res. 2018, 78(13 Supplement)
CoA	CoA of AZD5991

Smiles:	CN1N=C2CSCC3=NN(C)C(C)=C3C3=C4N(C)C(C(O)=O)=C(CCCOC5=C6C=CC=CC6=CC(SCC1=C2)=C5)C4=CC=C3Cl


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