Pralsetinib

Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor. Pralsetinib (BLU-667) inhibits WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion with IC50s of 0.4, 0.3, 0.4, 0.4, and 0.4 nM, respectively.


Cat. No.: EX-A1944	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
100mg	750	In-stock
250mg	1350	In-stock

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Synonyms	Blu-667
Synonyms 2	Blu667
CAS No.	2097132-94-8
Purity	>98%
Formula	C27H32FN9O2
Mol Weight	533.6005
Appearance	Solid powder
Solubility	DMSO > 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Subbiah V, et al. Precision Targeted Therapy With BLU-667 for RET-Driven Cancers. American Association for Cancer Research. 10.1158/2159-8290.CD-18-0338.
CoA	CoA of Pralsetinib

Smiles:	CO[C@]1(CC[C@@H](CC1)C1=NC(NC2=NNC(C)=C2)=CC(C)=N1)C(=O)N[C@@H](C)C1=CC=C(N=C1)N1C=C(F)C=N1


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