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Product Information:

AZD-4205

AZD4205 is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.7 μM), and shows little inhibition on JAK3 (IC50>30 μM).

Cat. No.: EX-A2671    Purity: >98%
AZD-4205
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg585In-stock
200mg925In-stock
500mg1650In-stock
1g2850In-stock
5g7865In-stock
10g11850In-stock


SynonymsGolidocitinib
CAS No.2091134-68-6
Purity>98%
FormulaC25H31N9O2
Mol Weight489.5727
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Su, Qibin et al. “Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor.” Journal of medicinal chemistry vol. 63,9 (2020): 4517-4527.

[2]. Annika Birgitta Margareta ÅSTRAND, et al. Compounds and methods for inhibiting jak. WO2017050938A1.
CoACoA of AZD-4205
Smiles:COC1=NN(C)C=C1NC1=NC=CC(=N1)C1=CNC2=C(NC(=O)[C@@H](C)N3CCN(C)CC3)C=CC=C12

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