INCB053914 phosphate

INCB053914 phosphate is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC50s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. INCB053914 phosphate has broad anti-proliferative activity against a variety of hematologic tumor cell lines.


Cat. No.: EX-A2737	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	665	In-stock
50mg	950	In-stock
100mg	1765	In-stock
200mg	2765	In-stock
500mg	3965	In-stock
1g	6400	In-stock

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Synonyms	PIM inhibitor 1 phosphate
CAS No.	2088852-47-3
Purity	>98%
Formula	C26H29F3N5O7P
Mol Weight	611.5067
Appearance	solid powder
Solubility	DMSO>50mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Koblish H, et al. Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies. PLoS One. 2018 Jun 21;13(6):e0199108.
CoA	CoA of INCB053914 phosphate

Smiles:	OP(O)(O)=O.C[C@H]1CN(C[C@@H](N)[C@@H]1O)C1=C2CC[C@@H](O)C2=NC=C1NC(=O)C1=NC(=C(F)C=C1)C1=C(F)C=CC=C1F


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