TAS0728

TAS0728 is a potent, selective, oral active, irreversible and covalent-binding HER2 inhibitor, binds to HER2 at C805, inhibits its kinase activity, with an IC50 of 13 nM.


Cat. No.: EX-A3171	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	480	In-stock
250mg	780	In-stock
500mg	1180	In-stock
1g	1980	In-stock
2g	3450	In-stock
5g	6850	In-stock

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CAS No.	2088323-16-2
Purity	>98%
Formula	C26H32N8O3
Mol Weight	504.5841
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Irie H, et al. TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models. Molecular cancer therapeutics. 2019;18(4):733-42. Epub 2019/02/23.
CoA	CoA of TAS0728

Smiles:	NC1=C2C(N([C@H]3CN(C(C=C)=O)CCC3)N=C2C(NC4=CC=C(CC(N(C)C)=O)C(C)=C4C)=O)=NC=N1


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