JNJ64619178

JNJ-64619178 is a selective, orally active and pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.14 nM. JNJ-64619178 has potent activity In lung cancer.


Cat. No.: EX-A2791	Purity: >98%

For research only, Do not use for Human!

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100mg	1185	In-stock
200mg	Get quote	In-stock
500mg	Get quote	In-stock
1g	Get quote	In-stock
5g	Get quote	inquire

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Synonyms	JNJ-64619178
Synonyms 2	Onametostat
CAS No.	2086772-26-9
Purity	>98%
Formula	C22H23BrN6O2
Mol Weight	483.361
Appearance	Solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Tongfei Wu, et al. Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models. [2]. Tao H, et al. Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations. Chem Pharm Bull (Tokyo). 2019;67(4):382-388.
CoA	CoA of JNJ64619178

Smiles:	NC1=NC=NC2=C1C=CN2[C@@H]1C[C@H](CCC2=CC3=NC(N)=C(Br)C=C3C=C2)[C@@H](O)[C@H]1O


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