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Product Information:

INCB-057643

INCB-057643 is a novel, orally bioavailable BET inhibitor.

Cat. No.: EX-A1908    Purity: >98%
INCB-057643
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg250Inquire
250mg400In-stock
500mg650In-stock
1g895In-stock
5g2800In-stock
10g4480In-stock


CAS No.1820889-23-3
Purity>98%
FormulaC20H21N3O5S
Mol Weight415.463
Appearancewhite to off-white powder
SolubilityDMSO >50mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Matthew C. Stubbs, et al. Abstract 5071: Preclinical characterization of the potent and selective BET inhibitor INCB057643 in models of hematologic malignancies. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5071.

[1]. Wilson AJ, Stubbs M, Liu P, Ruggeri B, Khabele D. The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer. Gynecol Oncol. 2018 Jun;149(3):575-584. doi: 10.1016/j.ygyno.2018.03.049. Epub 2018 Mar 20. PMID: 29567272; PMCID: PMC5986599.

CoACoA of INCB-057643
Smiles:CN1C=C(C2=C(NC=C2)C1=O)C1=CC(=CC2=C1OC(C)(C)C(=O)N2C)S(C)(=O)=O

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