PF-06650833

Zimlovisertib (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. Zimlovisertib is used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas.


Cat. No.: EX-A2502	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	550	In-stock
250mg	850	In-stock
500mg	1350	In-stock
1g	2200	In-stock
2g	3800	In-stock
5g	7500	In-stock

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Synonyms	Zimlovisertib
CAS No.	1817626-54-2
Purity	>98%
Formula	C18H20FN3O4
Mol Weight	361.3675
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Lee KL, et al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragmen [2]. Seganish WM. Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015). Expert Opin Ther Pat. 2016 Aug;26(8):917-32.
CoA	CoA of PF-06650833

Smiles:	CC[C@H]1[C@@H](COC2=NC=CC3=CC(C(N)=O)=C(OC)C=C23)NC(=O)[C@H]1F


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