SB-242084

SB 242084 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor.


Cat. No.: EX-A2270	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	750	In-stock
200mg	1150	In-stock
500mg	1750	In-stock
1g	2550	In-stock

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CAS No.	181632-25-7
Purity	>98%
Formula	C21H19ClN4O2
Mol Weight	394.854
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kennett GA, et al. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology. 1997 Apr-May;36(4-5):609-20. [2]. Harmon JL, et al. 5-HT2 Receptor Regulation of Mitochondrial Genes: Unexpected Pharmacological Effects of Agonists and Antagonists. J Pharmacol Exp Ther. 2016 Apr;357(1):1-9.
CoA	CoA of SB-242084

Smiles:	CC1=CC2=C(C=C1Cl)N(CC2)C(=O)NC1=CC=C(OC2=CC=CN=C2C)N=C1


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