ICEC 0942

ICEC0942, (PPDA-001 and CT7001), is a potent, orally active and selective CDK7 inhbitior. It selectively inhibits CDK7, with an IC50 of 40 nmol/L; IC50 values for CDK1, CDK2, CDK5, and CDK9 were 45-, 15-, 230-, and 30-fold higher. In vitro studies show that a wide range of cancer types are sensitive to CDK7 inhibition with GI50 values ranging between 0.2 and 0.3 μmol/L. In xenografts of both breast and colorectal cancers, the drug has substantial antitumor effects. In addition, combination therapy with tamoxifen showed complete growth arrest of ER-positive tumor xenografts. ICEC0942 may also be effective in other cancers that display characteristics of transcription factor addiction, such as acute leukaemia and small-cell lung cancer.


Cat. No.: EX-A3445	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	900	In-stock
100mg	1500	In-stock
250mg	2800	In-stock
500mg	5000	In-stock
1g	Get quote
5g	Get quote

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Synonyms	Samuraciclib HCl
Synonyms 2	PPDA-001
CAS No.	1805833-75-3
Purity	>98%
Formula	C22H30N6O
Mol Weight	394.5132
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

CoA	CoA of ICEC 0942

Smiles:	CC(C)C1=C2N=C(C=C(N2N=C1)NCC3=CC=CC=C3)NC[C@H]4CCNC[C@@H]4O


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