CAS No. | 1801747-11-4 |
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Purity | >98% |
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Formula | C16H20Cl3N5 |
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Mol Weight | 388.722 |
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Appearance | Solid powder |
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Solubility | DMSO 4mg/mL (Need ultrasonic and warming) |
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Shelf Life | >2 years if stored properly |
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Storage | Powder -20℃ 2 years; In solvent -20℃ 1 month; |
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Shipping | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
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Reference: | [1]. Garcia Fortanet J, et al. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 Sep 8;59(17):7773-82.
[2]. Chen YN, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016 Jul 7;535(7610):148-52.
[3]. Carmine Fedele, et al. SHP2 Inhibition Abrogates MEK inhibitor Resistance in Multiple Cancer Models. bioRxiv. April 25, 2018. |
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CoA | CoA of SHP099 hydrochloride |
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