KL-1333

KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures.


Cat. No.: EX-A3108	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	1350	In-stock
250mg	2250	In-stock
250mg	1550	In-stock
1g	Get quote	In-stock
5g	Get quote

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CAS No.	1800405-30-4
Purity	>98%
Formula	C14H12N2O2
Mol Weight	240.2573
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Seo KS, et al. KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Front Neurol. 2018;9:552. Published 2018 Jul 5. [2]. Lee HS, et al. KL1333, a derivative of β-lapachone, protects against cisplatin-induced ototoxicity in mouse cochlear cultures. Biomed Pharmacother. 2020;126:110068.
CoA	CoA of KL-1333

Smiles:	O=C(C1=C2N=C(C(C)C)N1)C(C3=C2C=CC=C3)=O


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