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Product Information:

Exatecan Mesylate

Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research.

Cat. No.: EX-A2579    Purity: >98%
Exatecan
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg600In-stock
250mg950In-stock
500mgGet quoteIn-stock
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SynonymsDX8951f
CAS No.169869-90-3
Purity>98%
FormulaC25H26FN3O7S
Mol Weight531.553
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.

[2]. Sun FX, et al. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res. 2003 Jan 1;63(1):80-5.

[3]. Joto N, et al. DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant. Int J Cancer. 1997 Aug 7;72(4):680-6.
CoACoA of Exatecan Mesylate
Smiles:CS(O)(=O)=O.CC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=C4[C@@H](N)CCC5=C4C(=CC(F)=C5C)N=C13)C2=O

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